DPPC და DPPA ლიპოსომების სხვადასხვა ლიგანდებთან წარმოქმნილი კომპლექსების თერმოდინამიკური კვლევა

Author: sandro muzashvili
Keywords: Liposome, Calcium, Cholesterol
Annotation:

Liposomes represent biocompatible drug carrier nanosystems which are capable to deliver drugs, incorporated in them, unaltered to damaged tissues. We wanted to find out whether cholesterol-containing liposomes would be formed without using an evaporator or not. According to results, by mixing DPPC lipids with water(in the presence of cholesterol), DPPC liposomes are still formed without using an evaporator, and later on, a gradual incorporation of cholesterol into newly formed liposomes also takes place during a heating process. That is, the suspension needs to be heated several times in order to occur the incorporation of cholesterol molecules into newly formed DPPC liposomes about in the same amount as in case of ready-prepared DPPC liposomes, prepared without using an evaporator, during the first heating cycle of the suspension. As to the other ligand – calcium – it plays an important role in cell homeostasis. A direct delivery of calcium-containing salts or ionic calcium to damaged tissues by liposomes is a very effective route